Advancements in Flexible Electrode Implantation for Invasive Brain-Computer Interfaces
DOI:
https://doi.org/10.54097/p581q821Keywords:
Intrusive brain-computer interface, flexible electrodes, electrode implantation.Abstract
In recent years, with the development of flexible electronic devices and advances in material science, flexible electrodes have played an important role in the field of invasive brain-computer interface (BCI). Compared with traditional rigid electrodes, flexible electrodes implanted in the brain cause less damage to brain tissue and are more biocompatible and stable. Most of the traditional invasive electrodes are made of glass or metal, which are prone to brain tissue damage, inflammation, and other problems, although they can avoid interference from the skull and skin and record neural signals accurately and with low noise. However, the main materials for flexible electrodes are polymers, hydrogels, graphene, etc., which can reduce immune rejection and prolong the service life of neural implants. This paper describes five main implantation methods for flexible electrodes in recent years: microneedle arrays, coiled implantation, minimally invasive injections, biodegradable electrodes, and stretchable electronics implantation. They can be used in the most appropriate way for electrodes of different structures to acquire neural signals with stable and reliable fidelity. Flexible electrodes have the potential for a wide range of applications in neuromonitoring providing a safer and more durable solution for invasive brain-computer interfaces. Then the authors will propose a new idea combining their respective advantages in the hope of bringing enlightenment.
Downloads
References
[1] Liu Yaoyao, et al. Nanomaterial-based microelectrode arrays for in vitro bidirectional brain–computer interfaces: a review. Microsystems & Nanoengineering, 2023, 9 (1): 13.
[2] Tang Xin, et al. Flexible brain–computer interfaces. Nature Electronics, 2023, 6 (2): 109-118.
[3] Kim Dae-Hyeong, et al. Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy. Nature materials, 2011, 10 (4): 316-323.
[4] Litt Brian, et al. Epileptic seizures may begin hours in advance of clinical onset: a report of five patients. Neuron, 2001, 30 (1): 51-64.
[5] Kim Tae-il, et al. Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. Science, 2013, 340 (6129): 211-216.
[6] Viventi Jonathan, et al. Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo. Nature neuroscience, 2011, 14 (12): 1599-1605.
[7] Liu, Jia, and Jia Liu. Syringe injectable electronics. Biomimetics Through Nanoelectronics: Development of Three Dimensional Macroporous Nanoelectronics for Building Smart Materials, Cyborg Tissues and Injectable Biomedical Electronics, 2018: 65-93.
[8] Hwang Suk-Won, et al. Biodegradable elastomers and silicon nanomembranes/nanoribbons for stretchable, transient electronics, and biosensors. Nano letters, 2015, 15 (5): 2801-2808.
[9] Minev Ivan, et al. Electronic dura mater for long-term multimodal neural interfaces. Science, 2015, 347 (6218): 159-163.
[10] Jing Xin, et al. Highly stretchable and biocompatible strain sensors based on mussel-inspired super-adhesive self-healing hydrogels for human motion monitoring. ACS applied materials & interfaces, 2018, 10 (24): 20897-20909.
[11] Zhao Qinai, et al. Highly stretchable and customizable microneedle electrode arrays for intramuscular electromyography. Science Advances, 2024, 10 (18): eadn7202.
[12] Park Dong-Wook, et al. Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications. Nature communications, 2014, 5 (1): 5258.
[13] Zhao Eric, et al. A CMOS-based highly scalable flexible neural electrode interface. Science Advances, 2023, 9 (23): 9524.
[14] Ramezani Mehrdad, et al. High-density transparent graphene arrays for predicting cellular calcium activity at depth from surface potential recordings. Nature Nanotechnology, 2024, 19 (4): 504-513.
[15] Kim Jejung, et al. Injectable 2D Material‐Based Sensor Array for Minimally Invasive Neural Implants. Advanced Materials, 2024: 2400261.
[16] Shouliang Guan, et al. Elastocapillary self-assembled neurotassels for stable neural activity recordings. Science advances, 2019, 5 (3): 2842.
[17] Li Xiao-Hong, et al. Low-intensity ultrasound ameliorates brain organoid integration and rescues microcephaly deficits. Brain, 2024: 150.
[18] Kim Dae-Hyeong, et al. Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. Nature materials, 2010, 9 (6): 511-517.
[19] Sekitani Tsuyoshi, et al. A rubberlike stretchable active matrix using elastic conductors. Science, 2008, 321 (5895): 1468-1472.
[20] Li Yang, et al. An injectable, self-healable, and reusable PEDOT: PSS/PVA hydrogel patch electrode for epidermal electronics. Nano Research, 2024, 17 (6): 5479-5490.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Highlights in Science, Engineering and Technology

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.