The Mechanism, Clinical Efficacy, and Application Optimization Strategies of Traditional Chinese Medicine in Combating Influenza Virus

Huaye Gong

doi:10.54097/cxfhae97

Authors

Huaye Gong

DOI:

https://doi.org/10.54097/cxfhae97

Keywords:

Influenza virus, Traditional Chinese medicine (TCM), Anti-influenza mechanism.

Abstract

Influenza is an acute respiratory infectious disease with fever, cough, and general discomfort as the main symptoms after infection with influenza virus, which can cause a certain proportion of deaths. Traditional Chinese medicine (TCM) has made great breakthroughs in the research and development of anti-influenza drugs with its unique effectiveness, and the field is also developing new drugs. A large number of clinical evidence also confirmed that some TCM ingredients such as berberine and forsythin can play a good role in anti-influenza virus in vivo and in vitro. In addition, some compound preparations, such as the Lianhua Qingwen capsule, have even played more important roles in clinical practice than Western medicine alone. However, the metabolic process in vivo and the synergy of different action sites need to be further clarified. Based on the pathogenic mechanism of the influenza virus, this paper further elaborated the mechanism of action of flavonoids, alkaloids, and other active ingredients of TCM on the virus, and then systematically summarized the clinical efficacy and effect of TCM against influenza and the application scheme of improving the combination of drugs. In addition, this topic provides a certain reference value for explaining the mechanism of TCM against the influenza virus and the methods of clinical use of TCM. However, there are still some problems to be further explored, such as the mechanism of TCM ingredients acting on the human body, the mechanism of action between TCM ingredients, and the safety of long-term use.

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References

[1] World Health Organization (WHO). Global Influenza Research Report 2025 [OL]. 2025 - 05 - 01 [2025 - 05 - 14].

[2] Han Xue. Research progress on antiviral activity and mechanism of Qingre Jiedu traditional Chinese medicine. Animal Husbandry and Veterinary Science and Technology Information, 2021 (06): 10 – 11.

[3] Dubaoxiang, Fu Yan, Sun Qihui, et al. Characterization of effective components of Guizhi Jiagegen Decoction in the treatment of influenza virus pneumonia based on serum pharmacochemistry of traditional Chinese medicine. Chinese Journal of Experimental Formulary, 2023, 29 (19): 168 – 175.

[4] Ding Y, Zeng L, Li R, Chen Q, Zhou B, Chen Q, et al. The Chinese prescription Lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function. BMC Complementary and Alternative Medicine, 2017, 17 (1): 130.

[5] Wei Chuang'e. Research progress on molecular biological characteristics and immunity of avian influenza virus. Animal Husbandry and Veterinary Science and Technology Information, 2007 (11): 26 – 27.

[6] Hartmann B M, Albrecht R A, Zaslavsky E, et al. Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death. Nature Communications, 2017, 8 (1): 1931.

[7] Zhang Wenqiang, Song Shaoxia, Wang Tongzhan. Research progress on the structure and function of HA protein of influenza A (H1N1) virus. Acta Virologica Sinica, 2012, 28 (04): 444 – 452.

[8] Li Li, Wang Linghang. Complications of influenza. Foreign Medicine: Virology Volume, 2018 (3).

[9] Lei Yuxuan, Shu Yuelong, Fang Shisong. Research progress of influenza-related central nervous system complications. Acta Virologica Sinica, 2022, 38 (01): 196 – 204.

[10] Gong Jinyan, Zhang Ying, Wu Xiaoqin. Research progress on antiviral activity of flavonoids. Chinese Herbal Medicine, 2008 (04): 623 – 627.

[11] Yang Linyao, Du Jiangchao, Shao Liang, et al. Flavonoids from Perilla frutescens and their anti-influenza activity. Journal of Kunming University of Science and Technology (Natural Science Edition), 2020, 45 (06): 104 – 110.

[12] Shi Yue, Shi Renbing, Liu Bin, et al. Study on flavonoids in anti-influenza virus effective fraction group of Yinqiao Powder. Chinese Journal of Traditional Chinese Medicine, 2001 (05): 32 – 35.

[13] Deng Jiu, Tao Yulong, He Yuqiong, et al. Research progress on anti-influenza virus active components and mechanism of action of Radix Isatidis. Chinese Journal of Traditional Chinese Medicine, 2021, 46 (08): 2029 – 2036.

[14] Zhou H-X, Li R-F, Wang Y-F, Shen L-H, Cai L-H, Weng Y-C, Zhang H-R, Chen X-X, Wu X, Chen R-F, Jiang H-M, Wang C Y, Yang M R, Lu J G, Luo X-D, Jiang Z H, Yang Z-F. Total alkaloids from Alstonia scholaris inhibit influenza A virus replication and lung immunopathology by regulating the innate immune response. Phytomedicine, 2020, 77(prepublish): 153272.

[15] Zhang Mingfa, Shen Yaqin. Research progress on antiviral clinical pharmacological effects of matrine alkaloids. Anti-infection Pharmacy, 2018, 15 (02): 185 – 191.

[16] Xing Shihua, Li Xiaobo. Research progress on antiviral activity and mechanism of action of heat-clearing and detoxifying traditional Chinese medicine. Chinese Pharmacological Bulletin, 2014, 30 (04): 464 – 468.

[17] Wang Yizhong, Cui Xiaolan, Gao Yingjie, et al. Antiviral test of Gardenia extract. Chinese Journal of Traditional Chinese Medicine, 2006 (14): 1176 – 1178.

[18] Luo R, Lv C, Wang T, et al. A potential Chinese medicine monomer against influenza A virus and influenza B virus: isoquercitrin. Chinese Medicine, 18 (1): 144 [2025 - 05 - 27].

[19] Gao Yang, Dong Xue, Kang Tingguo, et al. In vitro anti-influenza virus activity of arctigenin. Chinese Herbal Medicine, 2002 (08): 54 – 56.

[20] Cheng Yu, Chen Siyang, Chao Hong, et al. Comparative study on the effects of seven kinds of flavonoids on lipid metabolism and intestinal flora in mice fed with high-fat diet. Journal of Nutrition, 2025, 47 (01): 83 – 91.