Innovative Conservative Treatment for Female Patients with Anterior Cruciate Ligament Injury
DOI:
https://doi.org/10.54097/3343y307Keywords:
Anterior cruciate ligament injury; female; difference.Abstract
Anterior cruciate ligament (ACL) injury is among the most common knee disorders with significant gender differences in incidence. In sports with equivalent participation, ACL injury rates are 2-8 times greater in female athletes versus males, possibly due to differences in female anatomy, physiology, and biomechanics. Despite the abundance of conservative treatment options for ACL tears, there is still a gap in the design of data plans for the unique physiological characteristics of women. Based on the gender factors affecting the mechanism of ACL injury in women, this study aims to explore a multidisciplinary framework for female anatomical, estrogenic and biomechanical characteristics in order to optimize the existing conservative treatment options, namely strengthening the hip abductor muscle, the epinephalline muscle, core stability, landing cushioning training during physical therapy, and developing rehabilitation training programs combined with menstrual periods. In addition, collagen and amino acid supplements are added to daily nutritional supplements to promote ACL recovery; It is also possible to treat ACL tears with oral contraceptives.
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[1] Sugimoto D, Myer GD, Foss KD, Hewett TE. Specific exercise effects of preventive neuromuscular training intervention on anterior cruciate ligament injury risk reduction in young females: meta-analysis and subgroup analysis. Br J Sports Med. 2015 Mar;49(5):282-9. doi: 10.1136/bjsports-2014-093461. Epub 2014 Dec 1. PMID: 25452612.
[2] Mendiguchia J, Ford KR, Quatman CE, Alentorn-Geli E, Hewett TE. Sex differences in proximal control of the knee joint. Sports Med. 2011 Jul 1;41(7):541-57. doi: 10.2165/11589140-000000000-00000. PMID: 21688868; PMCID: PMC4221796.
[3] Jonasson G, Ghasemi MH, Jonsdottir US, Briem K, Sveinsson P. Effects of gender and fatigue on strength and activity of gluteus medius muscle during a controlled cutting maneuver in preadolescent athletes. J Electromyogr Kinesiol. 2023 Jun; 70:102779. doi: 10.1016/j.jelekin.2023.102779. Epub 2023 Apr 28. PMID: 37141731.
[4] Ford KR, Myer GD, Hewett TE. Valgus knee motion during landing in high school female and male basketball players. Med Sci Sports Exerc. 2003 Oct;35(10):1745-50. doi: 10.1249/01.MSS.0000089346. 85744.D9. PMID: 14523314.
[5] Dragoo JL, Castillo TN, Braun HJ, Ridley BA, Kennedy AC, Golish SR. Prospective correlation between serum relaxin concentration and anterior cruciate ligament tears among elite collegiate female athletes. Am J Sports Med. 2011 Oct;39(10):2175-80. doi: 10.1177/0363546511413378. Epub 2011 Jul 7. PMID: 21737831.
[6] Lee CA, Lee-Barthel A, Marquino L, Sandoval N, Marcotte GR, Baar K. Estrogen inhibits lysyl oxidase and decreases mechanical function in engineered ligaments. J Appl Physiol (1985). 2015 May 15;118(10):1250-7. doi: 10.1152/japplphysiol.00823.2014. Epub 2015 Apr 2. PMID: 25979936.
[7] Dragoo JL, Castillo TN, Braun HJ, Ridley BA, Kennedy AC, Golish SR. Prospective correlation between serum relaxin concentration and anterior cruciate ligament tears among elite collegiate female athletes. Am J Sports Med. 2011 Oct;39(10):2175-80. doi: 10.1177/0363546511413378. Epub 2011 Jul 7. PMID: 21737831.
[8] Konopka JA, DeBaun MR, Chang W, Dragoo JL. The Intracellular Effect of Relaxin on Female Anterior Cruciate Ligament Cells. Am J Sports Med. 2016 Sep;44(9):2384-92. doi: 10.1177/0363546516646374. Epub 2016 May 31. PMID: 27245459.
[9] Blasimann A, Busch A, Henle P, Bruhn S, Vissers D, Baur H. Neuromuscular control in males and females 1 year after an anterior cruciate ligament rupture or reconstruction during stair descent and artificial tibial translation. Sci Rep. 2023 Sep 15;13(1):15316. doi: 10.1038/s41598-023-42491-6. PMID: 37714980; PMCID: PMC10504317.
[10] El-Ashker S, Carson BP, Ayala F, De Ste Croix M. Sex-related differences in joint-angle-specific functional hamstring-to-quadriceps strength ratios. Knee Surg Sports Traumatol Arthrosc. 2017 Mar;25(3):949-957. doi: 10.1007/s00167-015-3684-7. Epub 2015 Jul 7. PMID: 26149462.
[11] Diermeier T, Rothrauff BB, Engebretsen L, Lynch AD, Ayeni OR, Paterno MV, Xerogeanes JW, Fu FH, Karlsson J, Musahl V, Svantesson E, Hamrin Senorski E, Rauer T, Meredith SJ; Panther Symposium ACL Treatment Consensus Group. Treatment after anterior cruciate ligament injury: Panther Symposium ACL Treatment Consensus Group. Knee Surg Sports Traumatol Arthrosc. 2020 Aug;28(8):2390-2402. doi: 10.1007/s00167-020-06012-6. Epub 2020 May 9. Erratum in: Knee Surg Sports Traumatol Arthrosc. 2022 Mar;30(3):1126. doi: 10.1007/s00167-020-06280-2. PMID: 32388664; PMCID: PMC7524809.
[12] Miyamoto D, Saito A, Kimoto M, Terui Y, Okada K. Relationship between the knee valgus moment and the hip abductor and adductor activity during single-leg landing. Phys Ther Sport. 2023 May; 61:129-134. doi: 10.1016/j.ptsp.2023.03.009. Epub 2023 Mar 29. PMID: 37023591.
[13] Behrens M, Mau-Moeller A, Wassermann F, Bruhn S. Effect of fatigue on hamstring reflex responses and posterior-anterior tibial translation in men and women. PLoS One. 2013;8(2): e56988. doi: 10.1371/journal.pone.0056988. Epub 2013 Feb 27. PMID: 23573178; PMCID: PMC3584125.
[14] Lapaeva AG, Tabakov RS, Tabakov SE, Miroshnikov AB, Smolensky AV. [Effect of dietary supplements and whey protein on muscle mass and strength of the operated limb after anterior cruciate ligament reconstruction: a systematic review]. Vopr Pitan. 2023;92(2):87-96. Russian. doi: 10.33029/0042-8833-2023-92-2-87-96. Epub 2023 Mar 1. PMID: 37346024.
[15] Konopka JA, Hsue LJ, Dragoo JL. Effect of Oral Contraceptives on Soft Tissue Injury Risk, Soft Tissue Laxity, and Muscle Strength: A Systematic Review of the Literature. Orthop J Sports Med. 2019 Mar 22;7(3):2325967119831061. doi: 10.1177/2325967119831061. PMID: 30923726; PMCID: PMC6431771.
[16] Rahr-Wagner L, Thillemann TM, Mehnert F, Pedersen AB, Lind M. Is the use of oral contraceptives associated with operatively treated anterior cruciate ligament injury? A case-control study from the Danish Knee Ligament Reconstruction Registry. Am J Sports Med. 2014 Dec;42(12):2897-905. doi: 10.1177/0363546514557240. PMID: 25428957.
[17] Akova B, Sürmen-Gür E, Gür H, Dirican M, Sarandöl E, Küçükoglu S. Exercise-induced oxidative stress and muscle performance in healthy women: role of vitamin E supplementation and endogenous oestradiol. Eur J Appl Physiol. 2001 Jan-Feb;84(1-2):141-7. doi: 10.1007/s004210000331. PMID: 11394244.
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