Study on the Mechanism of Immunoglobulin-Based Targeted Therapy in Tumor Immune Escape
DOI:
https://doi.org/10.54097/wfpq2855Keywords:
Immunoglobulin, targeted therapy, tumor immunity, clinical application, treatment effectAbstract
This article aims to explore the targeted therapy strategy based on immunoglobulin and its application and prospect in tumor immunotherapy. By reviewing the basic structure and classification of immunoglobulin, its role in immune system and its close relationship with tumor immunity, this article reveals the importance of immunoglobulin as a key molecule in immunotherapy. Furthermore, the principle of tumor immunotherapy with targeted immunoglobulin is expounded in detail, including specific methods such as immune checkpoint inhibitor therapy, antibody-coupled drug therapy and chimeric antigen receptor T cell therapy. At the same time, this article lists a variety of clinical application cases of cancer treatment, such as breast cancer, lymphoma and lung cancer, which shows the remarkable curative effect and wide application prospect of targeted therapy. Through the analysis of clinical data and the assessment of treatment effect, this article confirmed the remarkable effect of targeted therapy based on immunoglobulin in improving patient survival rate, tumor remission rate and quality of life. However, the follow-up still needs to be explored and optimized to achieve better therapeutic effects.
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[1] Xu L, Che S, Hou J Y. PPARγ agonist inhibits c‐Myc‐mediated colorectal cancer tumor immune escape[J]. Journal of cellular biochemistry. 2023, 124(8):1145-1154.
[2] Dong G, Wang Q, Wen M, et al. DDX18 drives tumor immune escape through transcription-activated STAT1 expression in pancreatic cancer[J]. Oncogene, 2023, 42(40): 3000-3014.
[3] Li Z, Wang J, Zhang X, et al. Proinflammatory S100A8 Induces PD-L1 Expression in Macrophages, Mediating Tumor Immune Escape[J]. The Journal of Immunology, 2020, 204(9):2589-2599.
[4] Jiao W, Feng Y, Liang C, et al. Reprogramming the tumor immune microenvironment via nanomaterial-mediated dynamic therapy[J]. Nano Research, 2023, 16(12):13100-13112.
[5] Ren P, Yu X, Yue Y X C. Dietary supplementation with astaxanthin enhances anti-tumor immune response and aids the enhancement of molecularly targeted therapy for hepatocellular carcinoma[J]. Food & Function, 2023, 14(18):8309-8320.
[6] Li X, He X, Lin B, et al. Quercetin Limits Tumor Immune Escape through PDK1/CD47 Axis in Melanoma[J]. The American Journal of Chinese Medicine, 2024, 52(02):541-563.
[7] Zhao L, Pei R, Ding Y, et al. LOXL4 Shuttled by Tumor Cells–derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis[J]. Journal of Immunotherapy, 2023, 47(2):64-76.
[8] Li X, Xu W. CD147 mediated reprogrammed glycolytic metabolism potentially induces immune escape in the tumor microenvironment[J]. Oncology reports, 2019, 41(5): 2945-2956.
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