Critical Influence of Prefrontal Cortex-hippocampus Interactions on False Memories

Hanjing Liu

doi:10.54097/peafjq74

Authors

Hanjing Liu

DOI:

https://doi.org/10.54097/peafjq74

Keywords:

False memory, prefrontal cortex, hippocampus, neuroscience, psychology

Abstract

This thesis addresses the important role of prefrontal-hippocampal circuits in the generation of false memories. First analyses the influence of prefrontal and hippocampus in the generation of false memories by separately analysing the semantic processing in the prefrontal lobe and the effect of high cognitive load on memory. As well as the impact of the memory extraction process and memory integration on memory in hippocampal function. Finally, the integrated effects of prefrontal-hippocampal circuits on false memories are discussed as a whole. This section includes questions about the interactions between the two, such as prefrontal inhibition of the hippocampus and the mechanisms by which the two are in situations of high cognitive load. The results indicate that the prefrontal-hippocampal circuit has a very critical influence on false memories. Processing on various mechanisms and functional aspects of the interaction between the two affects memory.

Downloads

Download data is not yet available.

References

[1] Bero, A., Meng, J., Cho, S., Shen, A., Canter, R., Ericsson, M., & Tsai, L. (2014). Early remodeling of the neocortex upon episodic memory encoding. Proceedings of the National Academy of Sciences, 111, 11852 - 11857. https://doi.org/10.1073/pnas.1408378111.

[2] Backus, A., Schoffelen, J., Szebényi, S., Hanslmayr, S., & Doeller, C. (2016). Hippocampal-Prefrontal Theta Oscillations Support Memory Integration. Current Biology, 26, 450-457. https://doi.org/10.1016/ j.cub.2015.12.048.

[3] Barch, D., Braver, T., Nystrom, L., Forman, S., Noll, D., & Cohen, J. (1997). Dissociating working memory from task difficulty in human prefrontal cortex. Neuropsychologia, 35, 1373-1380. https://doi. org/10.1016/S0028-3932(97)00072-9.

[4] Cutsuridis, V., & Wennekers, T. (2009). Hippocampus, microcircuits and associative memory. Neural networks : the official journal of the International Neural Network Society, 22 8, 1120-8 . https://doi.org/10.1016/j.neunet.2009.07.009.

[5] Carr, M., Jadhav, S., & Frank, L. (2011). Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval. Nature Neuroscience, 14, 147-153. https://doi.org/10.1038/nn.2732.

[6] Carpenter, A., & Schacter, D. (2017). Flexible Retrieval: When True Inferences Produce False Memories. Journal of Experimental Psychology: Learning, Memory, and Cognition, 43, 335–349. https://doi.org/10.1037/xlm0000340.

[7] Carpenter, A., Thakral, P., Preston, A., & Schacter, D. (2021). Reinstatement of item-specific contextual details during retrieval supports recombination-related false memories. NeuroImage. https://doi.org/ 10.1016/j.neuroimage.2021.118033.

[8] Das, A., & Menon, V. (2021). Asymmetric Frequency-Specific Feedforward and Feedback Information Flow between Hippocampus and Prefrontal Cortex during Verbal Memory Encoding and Recall. The Journal of Neuroscience, 41, 8427 - 8440. https://doi.org/10.1523/JNEUROSCI.0802-21.2021.

[9] Dolcos, F., LaBar, K., & Cabeza, R. (2004). Dissociable effects of arousal and valence on prefrontal activity indexing emotional evaluation and subsequent memory: an event-related fMRI study. NeuroImage, 23, 64-74. https://doi.org/10.1016/j.neuroimage.2004.05.015.

[10] Funahashi, S. (2017). Working Memory in the Prefrontal Cortex. Brain Sciences, 7. https://doi.org/10.3 390/brainsci7050049.

[11] Goldman-Rakic, P. (1996). The prefrontal landscape: implications of functional architecture for understanding human mentation and the central executive.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 351 1346, 1445-53 . https://doi.org/10.1098/ RSTB.1996.0129.

[12] Hoge, J., & Kesner, R. (2007). Role of CA3 and CA1 subregions of the dorsal hippocampus on temporal processing of objects. Neurobiology of Learning and Memory, 88, 225-231. https://doi.org/10.1016/ j.nlm.2007.04.013.

[13] Howard, M., & Eichenbaum, H. (2013). The hippocampus, time, and memory across scales.. Journal of experimental psychology. General, 142 4, 1211-30 . https://doi.org/10.1037/a0033621.

[14] Howard, M., MacDonald, C., Tiganj, Z., Shankar, K., Du, Q., Hasselmo, M., & Eichenbaum, H. (2014). A Unified Mathematical Framework for Coding Time, Space, and Sequences in the Hippocampal Region. The Journal of Neuroscience, 34, 4692 - 4707. https://doi.org/10.1523/JNEUROSCI.5808-12.2014.

[15] Haimerl, C., Angulo-García, D., Villette, V., Reichinnek, S., Torcini, A., Cossart, R., & Malvache, A. (2018). Internal representation of hippocampal neuronal population spans a time-distance continuum. Proceedings of the National Academy of Sciences, 116, 7477 - 7482. https://doi.org/10.1073/ pnas.1718518116.

[16] Jeye, B., Karanian, J., & Slotnick, S. (2017). The Anterior Prefrontal Cortex and the Hippocampus Are Negatively Correlated during False Memories. Brain Sciences, 7. https://doi.org/10.3390/brainsci70 10013.

[17] Kubota, Y., Toichi, M., Shimizu, M., Mason, R. A., Findling, R. L., Yamamoto, K., & Calabrese, J. R. (2006). Prefrontal hemodynamic activity predicts false memory—a near-infrared spectroscopy study. Neuroimage, 31(4), 1783-1789.

[18] Kim, H., & Cabeza, R. (2007). Differential contributions of prefrontal, medial temporal, and sensory-perceptual regions to true and false memory formation.. Cerebral cortex, 17 9, 2143-50 . https://doi.org/10.1093/CERCOR/BHL122.

[19] Kopelman, M. (1999). VARIETIES OF FALSE MEMORY. Cognitive Neuropsychology, 16, 197-214. https://doi.org/10.1080/026432999380762.

[20] Laroche, S., Davis, S., & Jay, T. (2000). Plasticity at hippocampal to prefrontal cortex synapses: Dual roles in working memory and consolidation. Hippocampus, 10. https://doi.org/10.1002/1098-1063(2000)10:4<438::AID-HIPO10>3.0.CO;2-3.

[21] Legon, W., Punzell, S., Dowlati, E., Adams, S., Stiles, A., & Moran, R. (2016). Altered Prefrontal Excitation/Inhibition Balance and Prefrontal Output: Markers of Aging in Human Memory Networks.. Cerebral cortex, 26 11, 4315-4326 . https://doi.org/10.1093/cercor/bhv200.

[22] Laroche, S., Davis, S., & Jay, T. (2000). Plasticity at hippocampal to prefrontal cortex synapses: Dual roles in working memory and consolidation. Hippocampus, 10. https://doi.org/10.1002/1098-1063(2000)10:4<438::AID-HIPO10>3.0.CO;2-3.

[23] Longe, O., Senior, C., & Rippon, G. (2009). The Lateral and Ventromedial Prefrontal Cortex Work as a Dynamic Integrated System: Evidence from fMRI Connectivity Analysis. Journal of Cognitive Neuroscience, 21, 141-154. https://doi.org/10.1162/jocn.2009.21012.

[24] Liu, C., Ye, Z., Chen, C., Axmacher, N., & Xue, G. (2021). Hippocampal Representations of Event Structure and Temporal Context during Episodic Temporal Order Memory.. Cerebral cortex. https://doi. org/10.1093/cercor/bhab304.

[25] Morris, R. (2006). Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas. European Journal of Neuroscience, 23. https://doi.org/10.1111/ j.1460-9568.2006.04888.x.

[26] Morris, R., Moser, E., Riedel, G., Martin, S., Sandin, J., Day, M., & O’Carroll, C. (2003). Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 358 1432, 773-86 . https://doi.org/10.1098/RSTB.2002.1264.

[27] Mirandola, C., & Toffalini, E. (2016). Arousal-But Not Valence-Reduces False Memories at Retrieval. PloS one, 11(3), e0148716. https://doi.org/10.1371/journal.pone.0148716

[28] Maingret, N., Girardeau, G., Todorova, R., Goutierre, M., & Zugaro, M. (2016). Hippocampo-cortical coupling mediates memory consolidation during sleep. Nature Neuroscience, 19, 959-964. https://doi.org/ 10.1038/nn.4304.

[29] Moscovitch, M., Rosenbaum, R., Gilboa, A., Addis, D., Westmacott, R., Grady, C., McAndrews, M., Levine, B., Black, S., Winocur, G., & Nadel, L. (2005). Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory. Journal of Anatomy, 207. https://doi.org/10.1111/j.1469-7580.2005.00421.x.

[30] O'Reilly, R. C., & Frank, M. J. (2006). Making working memory work: a computational model of learning in the prefrontal cortex and basal ganglia. Neural computation, 18(2), 283–328. https://doi.org/10.1162/ 089976606775093909

[31] Place, R., Farovik, A., Brockmann, M., & Eichenbaum, H. (2016). Bidirectional prefrontal-hippocampal interactions support context-guided memory. Nature neuroscience, 19, 992 - 994. https://doi.org/10.10 38/nn.4327.

[32] Preston, A., & Eichenbaum, H. (2013). Interplay of Hippocampus and Prefrontal Cortex in Memory. Current Biology, 23, R764-R773. https://doi.org/10.1016/j.cub.2013.05.041.

[33] Prasad, D., & Bainbridge, W. (2021). The Visual Mandela Effect as Evidence for Shared and Specific False Memories Across People. Psychological Science, 33, 1971 - 1988. https://doi.org/10.1177/ 09567976221108944.

[34] Patihis, L., Frenda, S., LePort, A., Petersen, N., Nichols, R., Stark, C., McGaugh, J., & Loftus, E. (2013). False memories in highly superior autobiographical memory individuals. Proceedings of the National Academy of Sciences, 110, 20947 - 20952. https://doi.org/10.1073/pnas.1314373110.

[35] Roediger, H. L., & McDermott, K. B. (1995). Creating false memories: Remembering words not presented in lists. Journal of Experimental Psychology: Learning, Memory, and Cognition, 21(4), 803-814. https://doi.org/10.1037/0278-7393.21.4.803

[36] Rolls, E., & Kesner, R. (2006). A computational theory of hippocampal function, and empirical tests of the theory. Progress in Neurobiology, 79, 1-48. https://doi.org/10.1016/j.pneurobio.2006.04.005.

[37] Wagner, A., Maril, A., Bjork, R., & Schacter, D. (2001). Prefrontal Contributions to Executive Control: fMRI Evidence for Functional Distinctions within Lateral Prefrontal Cortex. NeuroImage, 14, 1337-1347. https://doi.org/10.1006/nimg.2001.0936.

[38] Xu, W., & Südhof, T. (2013). A Neural Circuit for Memory Specificity and Generalization. Science, 339, 1290 - 1295. https://doi.org/10.1126/science.1229534.