Memory Reconstruction: A Novel Therapeutic Approach to Psychosis

Authors

  • Zifei Yan

DOI:

https://doi.org/10.54097/c3w7hw39

Keywords:

Psychosis; memory reconstruction; pathological memory; plasticity threshold.

Abstract

In the post-COVID-19 era, the rapid changes in the pace of life and the continuous increase in social pressure have led to an escalation in the number of patients with psychosis, which makes the negative impacts at the family and social levels expand. Currently, psychosis patients are mainly healed through medication, psychotherapy, and physical therapy. Most treatment approaches focus on the alleviation of pathological symptoms. However, there is still a deficiency in essential understanding of the more fundamental pathogenic factors and precise abnormal functional regions, thus leaving several gaps in precision medicine. Based on the principle of neural plasticity, this paper elaborates on the neural mechanism of pathological memory and the theoretical basis of memory reconsolidation methods, focusing on the intrinsic mechanisms of mental disorders and pathological memory, and analyzing the deep connection between pathological memory and neural plasticity in psychosis patients. By proposing the conceptual hypothesis of "plasticity threshold", it explores the possible role of memory reconsolidation technology in the treatment of psychosis, providing a reference for the precision medical treatment plan of this technology in such diseases.

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References

[1] Zhang, Y. How to Distinguish Between Mental Illness and Psychological Disorders[J]. Everyone's Health, 2024(23):78.

[2] Yao, J., & Zhang, Y. N. Comparison of the Effects of Quetiapine and Olanzapine in the Treatment of Senile Psychosis[J]. Journal of Clinical Rational Drug Use, 2025, 18(02):52 - 54+61.

[3] Guan, J., & Wu, X. C. Motivational Interviewing Combined with Cognitive Behavioral Therapy for Problematic Internet Use in Adolescents: A Case Study[J/OL]. Chinese Journal of Clinical Psychology, 2025(01):202 - 208[2025].

[4] Xue, K. K., Chen, J. L., Wei, Y. R., et al. Abnormal patterns of resting-state functional connectivity within and between large-scale brain networks in first-episode schizophrenia patients[J]. Chinese Journal of Medical Imaging Technology, 2023, 39(06):829 - 833.

[5] Zeng, C. J., Huang, J., Zhang, P. H., et al. An empirical study on the effect of low-frequency repetitive transcranial magnetic stimulation on suicidal ideation in adolescent patients with depression[J]. Psychological Monthly, 2025, 20(03):149 - 151+209.

[6] Power, J. D., & Schlaggar, B. L. Neural plasticity across the lifespan[J]. Wiley interdisciplinary reviews. Developmental biology, 2017, (1).

[7] Froemke, R. C., & Young, L. J. Oxytocin, Neural Plasticity, and Social Behavior[J]. Annual review of neuroscience, 2021, 44:359 - 381.

[8] Liu, X., et al. Optogenetic stimulation of a hippocampal engram activates fear memory recall[J]. Nature, 2012, 484:381 - 385.

[9] Frankland, P. W., Josselyn, S. A., & Köhler, S. The neurobiological foundation of memory retrieval[J]. Nature Neuroscience, 2019, 22(10):1576 - 1585.

[10] Asok, A., Leroy, F., Rayman, J. B., & Kandel, E. R. Molecular Mechanisms of the Memory Trace[J]. Trends in neurosciences, 2019, 42(1):14 - 22.

[11] Courtin, J., Gonzalezcampo, C., & Herry, C. Neural Mechanisms of Extinction Learning and Retrieval[J]. Springer US, 2012.

[12] Puderbaugh, M., & Emmady, P. D. Neuroplasticity[M]//StatPearls. StatPearls Publishing, 2023.

[13] Ward, N. S. Neural plasticity and recovery of function[J]. Progress in brain research, 2005, 150:527 - 535.

[14] Stiles, J. Neural plasticity and cognitive development[J]. Developmental neuropsychology, 2000, 18(2):237 - 272.

[15] Miki, Y., Tanji, K., Shinnai, K., et al. The pathological substrate of memory impairment in multiple system atrophy[J]. Neuropathology and applied neurobiology, 2022, 48(7):e12844.

[16] López, A. J., Hecking, J. K., & White, A. O. The Emerging Role of ATP - Dependent Chromatin Remodeling in Memory and Substance Use Disorders[J]. International journal of molecular sciences, 2020, 21(18):6816.

[17] Luo, Y. X., Xue, Y. X., Liu, J. F., et al. A novel UCS memory retrieval - extinction procedure to inhibit relapse to drug seeking[J]. Nature Communications, 2015, 6:7675.

[18] Gilbertson, M. W., Shenton, M. E., Ciszewski, A., et al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma[J]. Nature Neuroscience, 2002, 5(11):1242 - 1247.

[19] Shin, L. M., Rauch, S. L., & Pitman, R. K. Amygdala, medial prefrontal cortex, and hippocampal function in PTSD[J]. Annals of the New York Academy of Sciences, 2006, 1071:67 - 79.

[20] Felmingham, K., Kemp, A., Williams, L., et al. Changes in anterior cingulate and amygdala after cognitive behavior therapy of posttraumatic stress disorder[J]. Psychological science, 2007, 18(2):127 - 129.

[21] Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus[J]. The Journal of neuroscience: the official journal of the Society for Neuroscience, 2000, 20(24):9104 - 9110.

[22] Reed, B. R., Eberling, J. L., Mungas, D., et al. Memory failure has different mechanisms in subcortical stroke and Alzheimer's disease[J]. Annals of Neurology, 2000, 48(3):275 - 284.

[23] Qian, H. C., Zhang, P. S., Yuan, X. D., et al. Advances in the Study of Brain Networks and Event-Related Potentials of Cognitive Impairment in Post-Stroke Cognitive Impairment and Sleep Disorders[J]. Journal of Neurological and Mental Disorders, 2023, 23(10):742 - 747.

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Published

27-06-2025

How to Cite

Yan, Z. (2025). Memory Reconstruction: A Novel Therapeutic Approach to Psychosis. Highlights in Science, Engineering and Technology, 144, 226-233. https://doi.org/10.54097/c3w7hw39