Research Progress on the Application of Blue Light Irradiation Combined with Oral Probiotics in Neonatal Jaundice

Abstract

The incidence rate of NNJ in the newborn population is quite high, which can cause serious consequences such as bilirubin encephalopathy when serious, and pose a serious threat to the health of newborns, so it has always been a research hotspot in the field of pediatrics. At present, methods such as phototherapy and drug therapy are widely used for the treatment of neonatal jaundice, and their efficacy and mechanisms have been explored by many scholars. The role of gut microbiota in the occurrence and development of NNJ has also gradually been emphasized. However, the specific mechanisms of action of different probiotic strains against NNJ are not fully understood. This article provides an in-depth analysis of the effects of various probiotic strains on the intestinal barrier function, bilirubin metabolism related enzyme activity, and immune regulation of NNJ children. It was found that specific probiotics can significantly enhance the intestinal barrier, regulate enzyme activity, and optimize immune status to improve symptoms. This study provides a useful reference for the precise selection of probiotics for the treatment of neonatal jaundice. However, the impact of differences in gut microbiota among newborns of different regions and races on the efficacy of probiotics is still unclear. Subsequent research can focus on the development of personalized probiotic treatment plans and the direction of large-scale multicenter clinical trials.