Research Progress on the Role of Vitamin D in Preventing Gestational Diabetes
DOI:
https://doi.org/10.54097/srcytz96Keywords:
Vitamin D, gestational diabetes, medical nutrition therapy.Abstract
Research on the prevention and treatment of gestational diabetes mellitus (GDM), which poses a major threat to the health of both mothers and children, has to increase as living standards have increased. Numerous investigations into the pathophysiology of GDM, such as chronic insulin resistance, islet beta cell dysfunction, and other factors, have been carried out recently. Numerous studies have also examined the relationship between vitamin D and GDM, concluding that vitamin D deficiency may be linked to the development of GDM and that vitamin D supplementation can help GDM patients. The results of the research, however, are conflicting because of the influence of numerous factors, making it impossible to say if vitamin D supplementation is a prerequisite for the prevention and management of GDM. This article reviews the research progress on the prevention of GDM by analyzing the relationship between vitamin D and GDM. Future research should expand sample sizes, integrate multiple influencing factors, and investigate the precise relationship between vitamin D and GDM to develop more authoritative prevention and treatment strategies.
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[1] He Jing, et al. The experiences of pregnant women with gestational diabetes mellitus: A systematic review of qualitative evidence [J]. Reviews in Endocrine & Metabolic Disorders, 2020, 22(4): 777-787.
[2] Wang Cong, et al. The Impact of Early Personalized Health Management on the Incidence of Gestational Diabetes Mellitus in High-Risk Populations [J]. Chinese Journal of Maternal and Child Health Research, 2024, 35(6): 51-56.
[3] He Linghua. Evaluation of the Intervention Effects of Individualized Medical Nutrition Therapy Combined with Exercise Therapy on Gestational Diabetes Mellitus [J]. Chinese Medical Guide, 2023, 21(35): 93-95.
[4] You Chang'e. The Effect of Duhah Concept-Based Nursing Intervention in Pregnant Women with Gestational Diabetes Mellitus under the Concept of Nutrition [J]. Practical Obstetrics and Endocrine Electronic Journal, 2024, 11(8): 147-149.
[5] Yang Xubo, Lai Jianqiang. Research Progress on the Relationship between Vitamin D and Gestational Diabetes Mellitus [J]. Chinese Food and Nutrition, 2022, 28(7): 68-73.
[6] Zhou Ya, Zhao Mei. Research Progress on the Relationship between Folic Acid and Gestational Diabetes Mellitus [J]. Chinese Food and Nutrition, 2020, 26(7): 77-80.
[7] Zhang Yihan, Zhu Yan, Liu Chunyan. The Correlation between Early Pregnancy Vitamin D and Gestational Diabetes Mellitus and Its Predictive Value [J]. Chinese Journal of Maternal and Child Health Care, 2021, 36(20): 4675-4678.
[8] Reid IR, Bolland MJ, Grey A. Effects of Vitamin D Supplements on Bone Mineral Density: A Systematic Review and Meta-analysis[J]. The Lancet, 2014, 383(9912): 146-155.
[9] Ge Shuwang. Study on Photochemical Synthesis of Vitamin D3 [M]. Master's Thesis, Southeast University, 2015.
[10] Liao Xiangpeng, et al. Guidelines for the Application of Vitamin D in Adult Bone Health (2014 Standard Edition) [J]. Chinese Journal of Osteoporosis, 2014, 20(9): 1011-1030.
[11] Del Valle, Heather B., et al., eds. Dietary Reference Intakes for Calcium and Vitamin D [M]. 2011.
[12] Burris, Heather H., and Carlos A. Camargo. Vitamin D and Gestational Diabetes Mellitus [J]. Current Diabetes Reports, 2014, 14: 1-6.
[13] Egan AM, Vellinga A, Harreiter J, et al. Epidemiology of Gestational Diabetes Mellitus According to IADPSG/WHO 2013 Criteria among Obese Pregnant Women in Europe [J]. Diabetologia, 2017, 60: 1913-1921.
[14] Plows JF, Stanley JL, Baker PN, et al. The Pathophysiology of Gestational Diabetes Mellitus [J]. International Journal of Molecular Sciences, 2018, 19(11): 3342.
[15] Phelps RL, Metzger BE, Freinkel N. Carbohydrate Metabolism in Pregnancy: XVII. Diurnal Profiles of Plasma Glucose, Insulin, Free Fatty Acids, Triglycerides, Cholesterol, and Individual Amino Acids in Late Normal Pregnancy [J]. American Journal of Obstetrics and Gynecology, 1981, 140: 730–736.
[16] Ryan EA, O'Sullivan MJ, Skyler JS. Insulin Action during Pregnancy: Studies with the Euglycemic Clamp Technique [J]. Diabetes, 1985, 34: 380–389.
[17] Buchanan TA, Xiang AH. Gestational Diabetes Mellitus [J]. The Journal of Clinical Investigation, 2005, 115(3): 485-491.
[18] Song Zhenxiang, Sun Huiqin, Sun Shengyu. Correlation Analysis between Serum 25-Hydroxyvitamin D and Insulin Resistance in Gestational Diabetes Mellitus [J]. Chinese Journal of Health Standards Management, 2024, 15(20): 13-16.
[19] Parsons JA, Brelje TC, Sorenson RL. Adaptation of Islets of Langerhans to Pregnancy: Increased Islet Cell Proliferation and Insulin Secretion Correlates with the Onset of Placental Lactogen Secretion [J]. Endocrinology, 1992, 130: 1459–1466.
[20] LAN Xulan. Analysis of the Relationship between Early Pregnancy Vitamin D Levels and Gestational Diabetes Mellitus [J]. Chinese Medical Guide, 2024, 22(31): 86-88.
[21] Liu Zhao, Zhao Linlin, Li Xia, et al. Study on the Interaction and Predictive Value of Early Pregnancy BMI and 25-(OH)D3 in Gestational Diabetes Mellitus[J]. International Journal of Obstetrics and Gynecology, 2024, 51(5): 541-545.
[22] Ma Ziwen, Ding Xiaoying, Chu Liming, et al. Analysis of the Interaction Effect of Mid-Pregnancy Vitamin D and Gestational Diabetes Mellitus [J]. Shanghai Journal of Preventive Medicine, 2024, 1-10. http://cnki2.699wx.cn/kcms/detail/31.1635.R.20241009.1130.004.html.
[23] Burris, Heather H., and Carlos A. Camargo. Vitamin D and Gestational Diabetes Mellitus [J]. Current Diabetes Reports, 2014, 14: 1-6.
[24] Cui Liru, Liu Tiantian, Li Wenhui, et al. Efficacy of Serum Vitamin D in Treating Overweight and Obese Gestational Diabetes Mellitus[J]. Journal of Chuanbei Medical College, 2023, 38(7): 965-968.
[25] Liu Bingdong, Li Limei, Cao Guorong. Effects of Vitamin D Combined with Novo Nordisk Insulin on Glucose and Lipid Metabolism and Insulin Resistance in Gestational Diabetes Mellitus [J]. Chinese Journal of Family Planning, 2023, 31(11): 2601-2605.
[26] Wang Yuna, GAO Xianshun, Yao Kerong. Correlation between Serum Vitamin D, Interleukin-17 Levels and Insulin Resistance Index in Gestational Diabetes Mellitus Patients [J]. Shaanxi Medical Journal, 2020, 49(11): 1429-1431+1439.
[27] Farrant H JW, Krishnaveni GV, Hill JC, et al. Vitamin D Insufficiency is Common in Indian Mothers but is Not Associated with Gestational Diabetes or Variation in Newborn Size[J]. European Journal of Clinical Nutrition, 2009, 63(5): 646-652.
[28] Park S, Yoon HK, Ryu HM, et al. Maternal Vitamin D Deficiency in Early Pregnancy is Not Associated with Gestational Diabetes Mellitus Development or Pregnancy Outcomes in Korean Pregnant Women in a Prospective Study [J]. Journal of Nutritional Science and Vitaminology, 2014, 60(4): 269-275.
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