Research Progress of Dietary Intervention Effect of Ketogenic Diet on Type II Diabetes Patients

Qiaoying Ruan

doi:10.54097/9cqz0909

Authors

Qiaoying Ruan

DOI:

https://doi.org/10.54097/9cqz0909

Keywords:

ketogenic diet; Diabetes mellitus type 2; dietary intervention.

Abstract

Control of carbohydrate intake is an important auxiliary means for Diabetes mellitus type 2(T2DM) management, and ketogenic diet (KD) as a new dietary pattern has attracted much attention in recent years. This article analyzes and systematically reviews the effects of KD on biochemical indicators and complications of type 2 diabetes (T2DM). Studies have shown that KD can effectively reduce blood sugar and lipid levels in the short term, and help to reduce weight, while also showing a certain improvement in cardiovascular disease and diabetic neuropathy and other complications. However, this dietary pattern may cause adverse reactions such as constipation and hypoglycemia during implementation, and there is currently a lack of long-term large-scale clinical study data to support its safety. Overall, KD shows promising application in the management of T2DM, but further optimization of dietary protocols and more in-depth clinical studies are needed to evaluate its long-term effects and potential risks.

Downloads

Download data is not yet available.

References

[1] Wheless J. W. (2008). History of the ketogenic diet. Epilepsia, 49 Suppl 8, 3–5.

[2] McGaugh, E., & Barthel, B. (2022). A Review of Ketogenic Diet and Lifestyle. Missouri medicine, 119(1), 84–88.

[3] Hartman, A. L., & Vining, E. P. (2007). Clinical aspects of the ketogenic diet. Epilepsia, 48(1), 31–42.

[4] Shilpa, J., & Mohan, V. (2018). Ketogenic diets: Boon or bane?. The Indian journal of medical research, 148(3), 251–253.

[5] Yuan, X., Wang, J., Yang, S., Gao, M., Cao, L., Li, X., Hong, D., Tian, S., & Sun, C. (2020). Effect of the ketogenic diet on glycemic control, insulin resistance, and lipid metabolism in patients with T2DM: a systematic review and meta-analysis. Nutrition & diabetes, 10(1), 38.

[6] Malone, J. I., & Hansen, B. C. (2019). Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?. Pediatric diabetes, 20(1), 5–9.

[7] Schiller, J. S., Lucas, J. W., Ward, B. W., & Peregoy, J. A. (2012). Summary health statistics for U.S. adults: National Health Interview Survey, 2010. Vital and health statistics. Series 10, Data from the National Health Survey, (252), 1–207.

[8] Tahrani, A. A., & Morton, J. (2022). Benefits of weight loss of 10% or more in patients with overweight or obesity: A review. Obesity (Silver Spring, Md.), 30(4), 802–840.

[9] Nitin S. (2010). HbA1c and factors other than diabetes mellitus affecting it. Singapore medical journal, 51(8), 616–622.

[10] Krebs, J. D., Bell, D., Hall, R., Parry-Strong, A., Docherty, P. D., Clarke, K., & Chase, J. G. (2013). Improvements in glucose metabolism and insulin sensitivity with a low-carbohydrate diet in obese patients with type 2 diabetes. Journal of the American College of Nutrition, 32(1), 11–17.

[11] Saslow, L. R., Mason, A. E., Kim, S., Goldman, V., Ploutz-Snyder, R., Bayandorian, H., Daubenmier, J., Hecht, F. M., & Moskowitz, J. T. (2017). An Online Intervention Comparing a Very Low-Carbohydrate Ketogenic Diet and Lifestyle Recommendations Versus a Plate Method Diet in Overweight Individuals with Type 2 Diabetes: A Randomized Controlled Trial. Journal of medical Internet research, 19(2), e36.

[12] Dyńka, D., Kowalcze, K., Charuta, A., & Paziewska, A. (2023). The Ketogenic Diet and Cardiovascular Diseases. Nutrients, 15(15), 3368.

[13] Enders, J., Elliott, D., & Wright, D. E. (2023). Emerging Nonpharmacologic Interventions to Treat Diabetic Peripheral Neuropathy. Antioxidants & redox signaling, 38(13-15), 989–1000.

[14] Cooper, M. A., Menta, B. W., Perez-Sanchez, C., Jack, M. M., Khan, Z. W., Ryals, J. M., Winter, M., & Wright, D. E. (2018). A ketogenic diet reduces metabolic syndrome-induced allodynia and promotes peripheral nerve growth in mice. Experimental neurology, 306, 149–157.

[15] Bonikowska, K., Magnusson, P., & Sjöholm, Å. (2018). LCHF-kost gav svår ketoacidos hos patienter med typ 2-diabetes - Intensivvård krävdes för att häva livshotande tillstånd [Life-threatening ketoacidosis in patients with type 2 diabetes on LCHF diet]. Lakartidningen, 115, E4AD.

[16] Ludwig D. S. (2020). The Ketogenic Diet: Evidence for Optimism but High-Quality Research Needed. The Journal of nutrition, 150(6), 1354–1359.

[17] Nisse, Y. E., Robert, S., Menetre, S., Raffo, E., & Demore, B. (2020). Ketogenic diet: a pharmaceutical guide for the management of drug therapy in the pediatric population. International journal of clinical pharmacy, 42(2), 326–330.