Combined Use of Probiotics and Vitamin D in Gestational Diabetes Mellitus

Abstract

Gestational diabetes mellitus (GDM) is a common pregnancy complication with significant health implications for both mother and child. This review explores the potential of probiotics and vitamin D supplementation as therapeutic strategies for managing GDM. Probiotics, beneficial gut bacteria, have been shown to improve glucose and lipid metabolism, reduce insulin resistance, and modulate the gut microbiota in GDM patients. Essential for the regulation of calcium homeostasis and the control of immune responses, vitamin D also possesses the ability to mitigate inflammation and boost insulin sensitivity. Additionally, its deficiency is frequently observed in GDM cases. Studies indicate that combining probiotics and vitamin D supplementation yields synergistic benefits, effectively improving blood sugar control, lipid profiles, and antioxidant status in GDM patients. This review highlights the promising therapeutic potential of probiotics and vitamin D in GDM management and highlights the imperative for additional investigation to refine therapeutic approaches and enhance the health outcomes for individuals with GDM.