The Potential Mechanisms and Therapeutic Approaches of Gut Microbiota and the Occurrence of Endometritis
DOI:
https://doi.org/10.54097/35xhmb86Keywords:
Endometritis, Gut microbiota, Mechanisms and Treatment.Abstract
Endometritis, a prevalent gynecological condition, remains incompletely understood in terms of its pathogenesis, with inflammatory responses being a key factor in its development. In recent years, a growing body of research has highlighted that gut microbiota imbalances may significantly impact the onset and progression of endometritis. Currently, antibiotics are the mainstay of clinical treatment for endometritis, but the emergence of drug resistance problems has brought many challenges to the treatment. Due to the incomplete clarification of the pathogenesis of endometritis, there is a lack of more targeted treatment strategies and methods. This study thoroughly examined the potential mechanisms linking gut microbiota to endometritis occurrence, and explored the corresponding treatment methods, initially screening out four possible action pathways and two potentially feasible treatment options, providing a theoretical basis and reference direction for subsequent related studies. However, these conclusions still need to be further verified through experimental studies. Future research should focus on conducting experimental work to deeply explore its mechanism and optimize the treatment strategy.
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[1] Han, Yi-Ling et al. Vaginal microbiome dysbiosis as a novel noninvasive biomarker for detection of chronic endometritis in infertile women. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics vol. 167, 3 (2024): 1034-1042.
[2] Dong, Yuqing et al. Combined Intestinal Metabolomics and Microbiota Analysis for Acute Endometritis Induced by Lipopolysaccharide in Mice. Frontiers in cellular and infection microbiology vol. 11 791373. 17 Dec. 2021.
[3] Hu, Xiaoyu et al. Gut microbiota mediate the protective effects on endometritis induced by Staphylococcus aureus in mice. Food & function vol. 11, 4 (2020): 3695-3705.
[4] Borella, Fulvio et al. Gut Microbiota and Gynecological Cancers: A Summary of Pathogenetic Mechanisms and Future Directions. ACS infectious diseases vol. 7, 5 (2021): 987-1009.
[5] Wastyk, Hannah C et al. Gut-microbiota-targeted diets modulate human immune status. Cell vol. 184, 16 (2021): 4137-4153.e14.
[6] Cao, Wenli et al. The effect of the female genital tract and gut microbiome on reproductive dysfunction. Bioscience trends vol. 17, 6 (2024): 458-474.
[7] Cicinelli, Ettore et al. Chronic endometritis: correlation among hysteroscopic, histologic, and bacteriologic findings in a prospective trial with 2190 consecutive office hysteroscopies. Fertility and sterility vol. 89, 3 (2008): 677-84.
[8] Fung, Candice, and Pieter Vanden Berghe. Functional circuits and signal processing in the enteric nervous system. Cellular and molecular life sciences: CMLS vol. 77, 22 (2020): 4505-4522.
[9] Hu, Mingjing et al. Short-Chain Fatty Acids Augment Differentiation and Function of Human Induced Regulatory T Cells. International journal of molecular sciences vol. 23, 10 5740. 20 May. 2022.
[10] Wang, Kexin et al. Protective Effect of Clostridium butyricum on Escherichia coli-Induced Endometritis in Mice via Ameliorating Endometrial Barrier and Inhibiting Inflammatory Response. Microbiology spectrum vol. 10, 6 (2022): e0328622.
[11] Cai, Jie et al. Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis. Cell host & microbe vol. 30, 3 (2022): 289-300.
[12] Agus, Allison et al. Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease. Cell host & microbe vol. 23, 6 (2018): 716-724.
[13] Talwar, Chandni et al. Identification of distinct stool metabolites in women with endometriosis for non-invasive diagnosis and potential for microbiota-based therapies. Med (New York, N.Y.), 100517. 11 Oct. 2024.
[14] Wang, Gang et al. Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding. Microbiome vol. 12, 1 59. 19 Mar. 2024.
[15] Wang, Jing et al. Gut microbiota contributes to the intestinal and extraintestinal immune homeostasis by balancing Th17/Treg cells. International immunopharmacology vol. 143, Pt 3 (2024): 113570.
[16] Viganò, Davide et al. Irritable bowel syndrome and endometriosis: New insights for old diseases. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver vol. 50, 3 (2018): 213-219.
[17] Ervin, Samantha M et al. Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens. The Journal of biological chemistry vol. 294, 49 (2019): 18586-18599.
[18] Yu, Pei-Hsiu et al. The pro-inflammatory and anti-inflammatory role of hyaluronic acid in endometriosis. Taiwanese journal of obstetrics & gynecology vol. 60, 4 (2021): 711-717.
[19] Ismael, Mohamedelfatieh et al. The Bacteriocins Produced by Lactic Acid Bacteria and the Promising Applications in Promoting Gastrointestinal Health. Foods (Basel, Switzerland) vol. 13, 23 3887. 2 Dec. 2024.
[20] Xu, Huishu et al. Vaginal colonization of Lactobacilli: Mechanism and function. Microbial pathogenesis vol. 198 (2025): 107141.
[21] Rose, Elizabeth C et al. Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function. International journal of molecular sciences vol. 22, 13 6729. 23 Jun. 2021.
[22] Imaoka, Akemi et al. Anti-inflammatory activity of probiotic Bifidobacterium: enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells. World journal of gastroenterology vol. 14, 16 (2008): 2511-6.
[23] Kim, Nayeon, and Changwon Yang. Butyrate as a Potential Modulator in Gynecological Disease Progression. Nutrients vol. 16, 23 4196. 4 Dec. 2024.
[24] Hu, Binhong et al. Effect of Inonotus obliquus polysaccharide on composition of the gut microbiota in mice with acute endometritis. PloS one vol. 16, 11 e0259570. 5 Nov. 2021.
[25] Cheng, Fang et al. Liriodendrin exerts protective effects against chronic endometritis in rats by modulating gut microbiota composition and the arginine/nitric oxide metabolic pathway. International immunopharmacology vol. 126 (2024): 111235.
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